Neuro-ophthalmology of Mitochondrial Diseases

Valérie Biousse; Nancy J. Newman

doi:10.1055/s-2001-17945

Seminars in Neurology, Table of Contents

Semin Neurol 2001; 21(3): 275-292
DOI: 10.1055/s-2001-17945

Neuro-ophthalmology of Mitochondrial Diseases

Valérie Biousse¹ ² , Nancy J. Newman¹ ² ³

¹Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia
²Department of Neurology, Emory University School of Medicine, Atlanta, Georgia
³Department of Neurological Surgery, Emory University School of Medicine, Atlanta, Georgia

Abstract

ABSTRACT

The afferent and efferent visual pathways within the central nervous system are frequently involved in mitochondrial diseases. Neuro-ophthalmic signs figure prominently and may be the presenting or even sole manifestation of these disorders. The four most common neuro-ophthalmic abnormalities seen in mitochondrial disorders are bilateral optic neuropathy, ophthalmoplegia with ptosis, pigmentary retinopathy, and retrochiasmal visual loss.

KEYWORD

Mitochondrial disease - optic neuropathy - Leber's hereditary optic neuropathy - ophthalmoplegia - CPEO - MELAS - pigmentary retinopathy - encephalopathy - homonymous hemianopia - cortical blindness

Full Text

References

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